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, Giovanni Mauri Deparmtent of interventional radiology, European istitute of oncology , Milan , Italy Search for other works by this author on: Oxford Academic Luca Nicosia, MD Postgraduate School of Radiology, Università degli Studi di Milano , Milan , Italy Search for other works by this author on: Oxford Academic Zhen Xu Department of Biomedical Engineering, University of Michigan , Ann Arbor, MI , USA Search for other works by this author on: Oxford Academic Salvatore Di Pietro Postgraduate School of Radiology, Università degli Studi di Milano , Milan , Italy Search for other works by this author on: Oxford Academic Lorenzo Monfardini Department of Radiology and diagnotic imaging, Poliambulazna di Brescia , Brescia , Italy Search for other works by this author on: Oxford Academic Guido Bonomo Deparmtent of interventional radiology, European istitute of oncology , Milan , Italy Search for other works by this author on: Oxford Academic Gianluca Maria Varano Deparmtent of interventional radiology, European istitute of oncology , Milan , Italy Search for other works by this author on: Oxford Academic Francesco Prada Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan , Italy Department of Neurological surgery, University of Virginia Health Sciences Center , Charlottesville, VA , USA Focused Ultrasound Foundation , Charlottesville, VA , USA Search for other works by this author on: Oxford Academic Paolo Della Vigna Deparmtent of interventional radiology, European istitute of oncology , Milan , Italy Search for other works by this author on: Oxford Academic Franco Orsi Deparmtent of interventional radiology, European istitute of oncology , Milan , Italy Search for other works by this author on: Oxford Academic
British Journal of Radiology, Volume 91, Issue 1083, 1 March 2018, 20170641, https://doi.org/10.1259/bjr.20170641
Published:
17 January 2018
Article history
Received:
29 August 2017
Revision received:
16 October 2017
Accepted:
16 November 2017
Published:
17 January 2018
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Giovanni Mauri, Luca Nicosia, Zhen Xu, Salvatore Di Pietro, Lorenzo Monfardini, Guido Bonomo, Gianluca Maria Varano, Francesco Prada, Paolo Della Vigna, Franco Orsi, Focused ultrasound: tumour ablation and its potential to enhance immunological therapy to cancer, British Journal of Radiology, Volume 91, Issue 1083, 1 March 2018, 20170641, https://doi.org/10.1259/bjr.20170641
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Various kinds of image-guided techniques have been successfully applied in the last years for the treatment of tumours, as alternative to surgical resection. High intensity focused ultrasound (HIFU) is a novel, totally non-invasive, image-guided technique that allows for achieving tissue destruction with the application of focused ultrasound at high intensity. This technique has been successfully applied for the treatment of a large variety of diseases, including oncological and non-oncological diseases. One of the most fascinating aspects of image-guided ablations, and particularly of HIFU, is the reported possibility of determining a sort of stimulation of the immune system, with an unexpected “systemic” response to treatments designed to be “local”. In the present article the mechanisms of action of HIFU are described, and the main clinical applications of this technique are reported, with a particular focus on the immune-stimulation process that might originate from tumour ablations.
© 2018 The Authors. Published by the British Institute of Radiology
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
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